28 articles - From Friday Jun 16 2023 to Friday Jun 23 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| J Crohns Colitis |
meta-analyses and systematic reviews
| Am J Clin Nutr |
A modular systematic review of antenatal interventions targeting modifiable environmental exposures in improving low birth weight. We conclude that there is a paucity of evidence from RCT on interventions that modify environmental risk factors during pregnancy to potentially improve birth outcomes. Magic bullets approach might not work and that it would be important to study the effect of the broader interventions, particularly in LMIC settings. Global interdisciplinary action to reduce harmful environmental exposures, is likely to help to reach global targets for LBW reduction and sustainably improve long-term population health. |
A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight. Provision of BPE, MMN and LNS to pregnant women in populations with undernutrition can reduce the risk of LBW and related outcomes. The benefits of O3FA and calcium supplementation to this population require further investigation. Targeting interventions to pregnant women who are not gaining weight has not been tested with RCTs. |
| J Crohns Colitis |
Efficacy and safety of advanced oral small molecules for inflammatory bowel disease: Systematic review and meta-analysis. JAKi and S1P receptor modulator therapies are effective in IBD for inducing clinical and endoscopic remission and, in some circumstances, histologic response. |
Prevalence of NUDT15 genetic variants and incidence of thiopurine-induced leukopenia in Inflammatory Bowel Disease: A systematic review and meta-analysis. NUDT15 variants are common and strongly predict TIL in IBD patients. Pre-treatment NUDT15 genotyping should be considered particularly in Asian populations to guide thiopurine dosing and prevent myelotoxicity. |
| Pancreatology |
Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis. Finally, we obtained preliminary evidence that the variant is associated with reduced CTRC mRNA levels in the pancreas. Taken together, the results indicate that CTRC variant c.180C>T is a clinically relevant risk factor, and should be considered when genetic etiology of CP is investigated. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: Results from the CANN randomized, controlled parallel-design study. These results suggest that co-supplementation with omega-3 PUFA and cocoa flavanols for 12 months does not improve cognitive outcomes in those with cognitive impairment. The trial was registered on (NCT02525198). |
Antenatal interventions to address harmful behaviors and psychosocial risk factors in the prevention of low birth weight. Professionally provided psychosocial support during pregnancy in general and specifically as a means to reduce smoking can potentially contribute to improved newborn health. The gaps in the investments for research and implementation of psychosocial interventions should be addressed to better meet the global targets in LBW reduction. |
Antenatal interventions to reduce risk of low birth weight related to maternal infections during pregnancy. At present, there is limited evidence from RCTs available for some potentially relevant interventions targeting maternal infections, which could be prioritized for future research. |
Associations of weight and body composition at birth with body composition and cardiometabolic markers in children aged 10 years: the Ethiopian iABC birth cohort study. BW and BFFM rather than BFM are predictors of height and fat-free mass index at 10 years. Children with higher BW and BFFM had greater insulin concentrations and HOMA-IR at 10 years of age. The birth cohort was registered at ISRCTN as ISRCTN46718296. |
Is the association between fruits and vegetables and preeclampsia due to higher dietary vitamin C and carotenoid intakes? High dietary vitamin C and carotenoid intake was not associated with preeclampsia. The protective effect of high fruit and vegetable density on the risk of preeclampsia and late-onset preeclampsia were not mediated through dietary vitamin C and carotenoids CONCLUSIONS: Evaluating other nutrients and bioactives in fruits and vegetables and their synergy is worthwhile, along with characterizing the effect of individual fruits or vegetables on preeclampsia risk. |
What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight. These promising interventions, coupled with increasing coverage of currently recommended antenatal care, could accelerate progress toward the global target of a 30% reduction in the number of LBW infants born in 2025 compared to 2006-10. |
| Inflamm Bowel Dis |
Attenuated Expression of SLCO2A1 Caused by DNA Methylation in Pediatric Inflammatory Bowel Disease. Local DNA methylation attenuated SLCO2A1 expression, which may evoke local inflammation of the mucosa by the unincorporated PG. These findings may improve our understanding of the epigenetic mechanisms underlying IBD development. |
SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis. Our study demonstrated that HKL could partially protect against colitis by regulating Th17 differentiation through activating SIRT3, leading to inhibition of the STAT3/ROR |
| J Crohns Colitis |
Disease recurrence and long-term outcomes following the development of intestinal failure in Crohn's disease: over 20 years of experience from a national reference centre. This is the largest series reporting disease behaviour and long-term outcomes in CD-IF and the first describing prophylactic therapy use. The incidence of disease recurrence was low. Immunosuppressive therapy appears to be safe in HPN-dependent patients with no increased risk of CRBSI. The management of CD-IF needs to be tailored to the patient's surgical disease history alongside disease phenotype. |
Gut microbiome generated phenylacetylglutamine from dietary protein is associated with Crohn's Disease and exacerbates colitis in mouse model possibly via platelet activation. Taken together, ppdc-carrying Proteobacteria generated PAGln from dietary protein is associated with CD and exacerbates colitis possibly via platelet-induced coagulation and inflammation These results suggest that PAGln is a potential early diagnostic marker and therapeutic target of CD. |
Lack of benefit for early escalation to advanced therapies in ulcerative colitis: critical appraisal of current evidence. The costs and risk/benefit profile of some of the newer advanced therapies should be carefully considered. In this clinical landscape, it appears premature to advocate an indiscriminate 'one size fits all' approach to escalating to advanced therapies early during the course of UC. |
| Liver Transpl |
One size does not fit all: Differential benefits of simultaneous liver-kidney transplantation by eligibility criteria. Benefit within the first year posttransplant associated with SLK over liver-alone transplantation was only pronounced in patients with ESKD, but not present in patients meeting other criteria for SLK. A "strict SLK liberal Safety Net" strategy may warrant consideration at the national policy level. |
| Pancreatology |
"Conversion surgery" for locally advanced pancreatic cancer: A position paper by the study group at the joint meeting of the International Association of Pancreatology (IAP) & Japan Pancreas Society (JPS) 2022. This article summarizes the agreement during the discussion amongst the experts in the meeting. We hope that this will serve as a foundation for future international collaboration and recommendations for future guidelines. |
Intraoperative pancreatoscopy can improve the detection of skip lesions during surgery for intraductal papillary mucinous neoplasia: A pilot study. Intraoperative pancreatoscopy is a safe and feasible procedure and might allow the detection of skip lesions during surgery for suspect MD-involving IPMNs. |
Maintaining early diagnosis of pancreatic adenocarcinoma in Japan: Local resilience against COVID-19. The pandemic advanced the stage of PA in our region. Although the pancreatic referral network remained functional during the pandemic, there were delays from disease onset to patients' first visit to healthcare providers, including clinics. While the pandemic caused temporary damage to PA practice, the routine regional collaboration provided by our institution's project allowed for early resilience. A notable limitation is that the impact of the pandemic on PA prognosis was not evaluated. |
Profile of and risk factors for early unplanned readmissions in patients with acute necrotizing pancreatitis. Patients with ANP have a significant risk for early (<30 days) readmission. Direct discharge to home, rather than short or long-term rehabilitation facilities, is associated with lower odds of early readmission. Analysis was otherwise negative for independent, clinical predictors of early unplanned readmissions in ANP. |
Significance of multiple tumor markers measurements in conversion surgery for unresectable locally advanced pancreatic cancer. Simultaneous measurement and assessment of the three TMs levels may help determine the surgical indications for UR-LAPC after systemic anticancer treatment. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| J Crohns Colitis |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
| Liver Transpl |
Letters to the editors and authors’ replies